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Cat. No. | Product Name | Target | Signaling Pathways |
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T3283 |
Cetilistat
新利司他,ATL-962 |
Lipid | Metabolism |
Cetilistat (ATL-962) 是胰腺脂肪酶 (pancreatic lipase) 抑制剂,能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性,可用作有效的抗肥胖药。 | |||
T63015 |
Pancreatic lipase/Carboxylesterase 1-IN-1
|
||
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂,作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。 | |||
T77668 |
hPL-IN-1
|
Others | Others |
hPL-IN-1 是一种有效的可逆胰脂肪酶 (PL) 抑制剂 (IC50=1.86 μM),可用于研究与肥胖相关的疾病。 | |||
T77679 |
hPL-IN-2
|
Others | Others |
hPL-IN-2 是一种具有有效性、可逆性、和非竞争性胰脂肪酶 (Pancreatic lipase) 抑制剂 (IC50: 1.63 μM),可用于研究肥胖相关疾病。 | |||
T39189 |
3,4,5-Trihydroxycinnamic acid decyl ester
|
||
3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties. Additionally, this compound acts as a pancreatic lipase inhibitor, with an EC 50 of around 0.9 μM. | |||
T41160 |
Lalistat 2
|
Lipase | Metabolism |
Lalistat 2 是一种溶酶体酸性脂肪酶的特异性抑制剂,IC50 为 152 nM,对人胰脂肪酶或牛乳脂蛋白脂肪酶没有抑制作用(高达 10 μM)。 | |||
T10768 |
Cetilistat impurity 1
|
Others | Others |
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat is an inhibitor of pancreatic lipase. Cetilistat inhibits rat and human pancreatic lipase activity (IC50s: 54.8 nM and 5.95 nM). | |||
T70882 |
Orlistat-d3
|
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Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... | |||
T35979 |
Benastatin C
|
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Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul... | |||
T36864 |
GRP (human) (trifluoroacetate salt)
|
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Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM. In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats. It dose-depend... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S1312 |
Gypsogenin-3-O-glucuronide
丝石竹皂苷元3-O-Β-D-葡萄糖醛酸甲酯,Methyl gypsogenin 3-O-beta-D-glucuronopy,丝石竹皂苷元-3-O-β-D-葡萄糖醛酸甲酯 |
Others | Others |
Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) 是一种皂角苷前体,普遍存在于满天星属植物中。 | |||
T5707 |
3-O-Methylgalangin
3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚 |
Antibacterial | Microbiology/Virology |
3-O-Methylgalangin (GALANGIN-3-METHYLETHER) 是一种来源于高良姜根茎的天然黄酮,具有抗菌活性,抑制胰腺脂肪酶。 | |||
T2840 |
Phloracetophenone
2,4,6-三羟基苯乙酮,2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone |
Others; P450; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology; Others |
Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) 是多叶姜黄中苯乙酮糖苷的糖苷配基部分,具有抗肥胖,降血脂和降低胆固醇作用,能够增强胆固醇 7α-羟化酶的活性。 | |||
T5S1389 |
Escin IB
七叶皂苷B,七叶皂苷 IB |
5-HT Receptor; NO Synthase | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Escin IB 是一种皂苷,分离自马栗子种子的皮和胚乳中,能够抑制 pancreatic lipase 的活性。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T40464 | Neotheaflavin | ||
Neotheaflavin, from black tea, inhibits pancreatic lipase. | |||
T83206 |
Acanthopanaxoside A
|
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Acanthopanaxoside A 为三萜类皂苷化合物,能够抑制胰腺脂肪酶 (lipase) 活性。 | |||
TN3118 |
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
|
Others | Others |
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity. | |||
T82712 |
Ciwujianoside C4
|
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Ciwujianoside C4,一种皂苷类化合物,在体外能够增强胰腺脂肪酶活性。 | |||
T75645 | Echitamine chloride | ||
Echitamine chloride 是存在于 Alstonia scholaris 中的主要单萜吲哚生物碱,具有有效的抗肿瘤活性。Echitamine chloride 会诱导 DNA 片段化和细胞凋亡 (apoptosis)。Echitamine chloride 抑制胰腺脂肪酶 (pancreatic lipase),IC50为 10.92 µM。 | |||
T82713 |
Ciwujianoside C1
|
||
Ciwujianoside C1, 一种从Acanthopanax senticosus叶中分离得到的皂苷,具有抑制体外胰腺脂肪酶活性的功能。 | |||
TN5463 |
Leachianone G
|
||
Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Leachianone G shows potent antiviral | |||
T83308 |
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl
|
||
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) 是从漏斗石斛 (D. infundibulum) 中分离出的化合物。该化合物不具有对 α-葡萄糖苷酶和胰脂肪酶的抑制活性。 | |||
TN4580 |
Morachalcone A
|
Tyrosinase | Proteases/Proteasome |
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai | |||
TN5682 |
2,6,4'-Trihydroxy-4-methoxybenzophenone
|
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2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neurotrophic activity, it induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml. 2,6,4â²-Trihydroxy-4-methoxybenzophenone exhibits low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 ug/ml and 158 ug/ml, repectively. It also shows antiox... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03222 |
PNLIP Protein, Human, Recombinant (His)
PL,pancreatic lipase,PTL,PNLIPD |
Human | HEK293 Cells |
PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which a... | |||
TMPY-00252 |
PNLIPRP1 Protein, Rat, Recombinant (His)
pancreatic lipase-related protein 1 |
Rat | HEK293 Cells |
PNLIPRP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52 kDa and the accession number is P54316. | |||
TMPY-03808 |
PNLIPRP1 Protein, Human, Recombinant (His)
pancreatic lipase-related protein 1,PLRP1 |
Human | HEK293 Cells |
PNLIPRP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.4 kDa and the accession number is AAH25784.1. | |||
TMPY-03182 |
PLRP2 Protein, Human, Recombinant (His)
PLRP2,pancreatic lipase-related protein 2 |
Human | Baculovirus Insect Cells |
Galactolipase, also known as PNLIPRP2, is a lipase with broad substrate specificity. It can hydrolyze both phospholipids and galactolipids. Galactolipase acts preferentially on monoglycerides, phospholipids and galactolipids. It also hydrolyses milk fat with a lower catalytic efficiency. The expressed galactolipase shows a lipolytic activity that is, however, only marginally dependent on the presence of colipase. The lipolytic activity of pancreatic extracts and human pancreatic juice on Labraso... | |||
TMPY-03353 |
CEL Protein, Mouse, Recombinant (His)
1810036E18Rik,carboxyl ester lipase,BAL |
Mouse | Baculovirus Insect Cells |
CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations in CEL c... |